Il Prof.Alessandro Frati è Professore Associato in Neurochirurgia presso l'Università degli Studi di Roma Sapienza. Vice Direttore della Scuola di Specializzazione n Neurochirurgia, presso la Facoltà di Medicina e Psicologia dell'Università di Roma La Sapienza. Si è laureato con lode in Medicina e Chirurgia nel 2000 presso l'Università degli Studi di Roma "La Sapienza", dove si è specializzato con lode nel 2005 in Neurochirurgia. Durante gli anni della specializzazione ha lavorato presso il “Brain Cancer Center” dell’Harvard Medical School del Massacchussets General Hospital di Boston, con il prof. R. Martuza nel 2002 dove si è specializzato nella chirurgia dei tumori cerebrali e spinali e nel reparto di Neurochirurgia della Miller School of Medicine dell’University of Miami, diretta dal dott. B. Green Miami nel 2003, dove si è specializzato in Microchirurgia. Nel 2008/2009 ha effettuato una fellowship presso la Capital Medical University di Pechino nel reparto di Neurochirurgia Spinale diretto dal prof. FZ. Jiang, specializzato nelle tecniche chirurgiche miniinvasive per la patologia degenerativa, traumatica e oncologica della colonna vertebrale . Dal 2007 al 2008 e dal 2009 al 2011 ha lavorato come Dirigente Medico di I livello presso la Neurochirurgia Universitaria dell'Ospedale S.M. Goretti di Latina. Dal 2012 ad oggi lavora come Dirigente Neurochirurgo di I livello, Professore Associato e Vice Direttore della Scuola di specializzazione in Neurochirurgia presso l'Azienda Ospedaliera/Universitaria Sant'Andrea, affiliata alla Sapienza Università di Roma.Le principali specializzazioni chirurgiche sono la microchirurgia dell'ernia del disco con tecniche miniinvasive per accelerare il recupero in sportivi e atleti; la chirurgia miniinvasiva della colonna vertebrale (ernie discali, instabilità, stenosi del canale, spondilolistesi, metastasi vertebrali, tumori vertebrali), la Chirurgia dei Tumori Cerebrali in Neuronavigazione, Awake Surgery (chirurgia da Sveglio), la Chirurgia dei Tumori Vertebrali e Midollari (Primitivi o Metastatici), la Chirurgia delle fratture vertebrali traumatiche, e la Neurotraumatologia Cranica (Ematomi, Fratture Craniche). In generale l'applicazione delle nuove tecnologie (Neuronavigatore, Monitoraggi neurofisiologici, protesi dinamiche) e delle tecniche miniinvasiva alla Neurochirurgia Cerebrale e spinaleHo eseguito circa 2000 interventi chirurgici di cui oltre 1000 interventi come primo operatore: circa 150 interventi l’anno come primo operatore negli ultimi 5 anni.Dal 2002 ha eseguito interventi cerebrali e spinali in Neuronavigazione (oltre 800, come primo operatore e aiuto) acquisendo una delle più importanti esperienze chirurgiche in Italia.CV IN ENGLISHAlessandro Frati is Associate Professor of Neurosurgery at the University of Rome “La Sapienza”, Vice Director of The Residency Program in Neurosurgery at the University of Rome “La Sapienza”,Consultant Neurosurgeon at Ospedale Sant’Andrea in Rome, affiliated hospital of the University of Rome “La Sapienza”. He is also Consultant Neurosurgeon for the Vatican State at “Casa di Cura Pio XI” Hospital in Rome since 2015 and Consultant for Research in Neurosurgery at the Scientific Research Institute (IRCCS) Neuromed (Pozzilli) since 2006. He is also consultant neurosurgeon for the Senate of the Italian republic since 2014. He is active member of the Italian Society of Neurosurgery since 2005.He was former consultant neurosurgeon for Scuderia Ferrari (Formula 1 Race Team) in 2014. Clinical and research activity:Both surgical and research fields of interest are mainly neurooncology (primary and metastatic spine and brain tumours), cerebrovascular surgery, degenerative disease of the spine, and in general the use of new technologies (Navigation, Laser, Neurphysiological monitoring) and minimally invasive techniquesin Neurosurgery. He has operated more 1000 cases as consultant neurosurgeon (first surgeon). He has got research grant as principal investigator in both clinical and basic research trial from the Italian National Institute of Teaching and Research for more than 1000000 Euro .BIBLIOGRAPHY: 84 DOCUMENTS AVAILABLE ON SCOPUSH index =20, Total impact factor= 221,2 Number of total citations=1171CURRICULUM VITAE OF SCIENTIFIC, CLINICAL AND TEACHING ACTIVITYCURRICULUM VITAE ET STUDIORUM. GENERAL DATA Name: Alessandro Frati, MDPLACE AND DATE OF BIRTH: Roma (ITALY), 23 Ottobre 1975 Office address: Università di Roma “La Sapienza” , Azienda Ospedaliera Sant’Andrea Via di Grottarossa, 103500189 ROMA3920426250 -3284775728 06.33776697 Email: alessandro.frati@uniroma1.it alex.frati@gmail.comA. Current Hospital and Academic Position: •Associate Professor of Neurosurgery at the University of Rome “La Sapienza”•Vice Director of The Residency Program in Neurosurgery at the University of Rome “La Sapienza”•Consultant Neurosurgeon at Ospedale Sant’Andrea in Rome, affiliated hospital of the University of Rome “La Sapienza”. •Consultant Neurosurgeon for the Vatican State. “Casa di Cura Pio XI” Hospital in Rome•Member of the Congregation for the Causes of Saints (Medical Committee) •Consultant for Research in Neurosurgery at the Scientific Research Institute (IRCCS) Neuromed (Pozzilli). •Consultant Neurosurgeon for the Senate of the Italian Republic.•Consultant Neurosurgeon for Scuderia Ferrari (Formula 1 Race Team: 2014 for Jules Bianchi case.) •Member of the Scientific Committee “ Sanità in Formazione” international provider for ECM course•Member of the Executive Committee of the Faculty of Medicine and Psychology at the University of Rome “La Sapienza”•Member of the Italian Committee for Abilitation of Foreign Neurosurgeon •Member of the PhD in Neurosurgery Program for the Faculty of Medicine and Psychology at the University of Rome “La Sapienza”B. Education . •1995-2000 Medical School at the University of Rome “La Sapienza”•1996-2000 Internship as Student Research Fellow in Neuroanatomy•1998-2000 Internship as Student Researc Fellow in Immunology•2000 [14.11.2000] MD University of Rome “La Sapienza”, graduation with praise• 2000-2005 Resident in Neurosurgery, University of Rome “La Sapienza”•2002 Internship in Neurosurgery as foreign resident at Massachusetts General Hospital, Boston, MA •2003 Internship in Neurosurgery as foreign resident at Jackson Memorial Hospital Miami, Loise Pope Life Center, University of Miami C. Licensure, Certification, Academic Appointments •2001 [8.11.2001] Italian Medical License Registration•2005 [14.11.2005] Italian Board for Consultant in Neurosurgery•2005 Active Member of the Italian Society of Neurosurgery (SINCH)• [01.11.2006- 01.11.2015] Assistant professor in Neurosurgery at the University of Rome “La Sapienza”•2006 Clinical and Research Consultant in Neurosurgery at IRCCS Neuromed, Pozzilli. University of Rome “La Sapienza”•2006 Director of the Microsurgical Lab at IRCCS Neuromed, Pozzilli. University of Rome “La Sapienza”•2008-2009 Clinical Fellowship at the Capital Medical University, Department of Neursurgery- Spine, Beijing /China)•2009 Visiting Professor at MGH, Boston (22-30.6.2009) at Brain Tumour Center with Dr Martuza.•2012 Vice Director of The Residency Program in Neurosurgery at the University of Rome “La Sapienza”, Faculty of Medicine and Psychology.•2015 Associate Professor in Neurosurgery at the University of Rome “La Sapienza”•2015. Member of the Scientific Committee “ Sanità in Formazione” international provider for ECM course•2015 Member of the Italian Committee for the Abilitation of Foreign Neurosurgeon •2017 Board of PhD in Neurosurgery Program for the Faculty of Medicine and Psychology at the University of Rome “La Sapienza”•2017 Board of PhD in Neurosurgery Program Directors for the Faculty of Medicine and Psychology at the University of Rome “La Sapienza” D. Clinical and Hospital Service Responsabilities•2006-2007 Consultant Neurosurgeon at IRCCS Neuromed, Pozzilli (Is). University of Rome “La Sapienza”•2007-2008 and 2009-2012 Consultant Neurosurgeon at S.Maria Goretti Hospital “Polo Pontino” affiliated hospital of the University of Rome “La Sapienza”. •2012.Consultant Neurosurgeon at Ospedale Sant’Andrea in Rome, affiliated hospital of the University of Rome “La Sapienza”. •2014. Consultant Neurosurgeon for Scuderia Ferrari (Formula 1 Race Team: 2014 for Jules Bianchi case.) •2015.Consultant Neurosurgeon for the Vatican State. “Casa di Cura Pio XI” Hospital in Rome•2015. Member of the Congregation for the Causes of Saints of the Vatican State (Medical Committee) •2015. Consultant Neurosurgeon for the Senate of the Italian Republic.•2014 Member of the Executive Committee of the Faculty of Medicine and Psychology at the University of Rome “La Sapienza”•2014-2016 2017 Member of the Committe for the PhD in Translational Medicine for the Faculty of Medicine of the University of Molise•2015 Member of the Italian Committee for Abilitation of Foreign Neurosurgeon •2017 Member of the Committe for the PhD Neurosurgical Program for the Faculty of Medicine and Psychology at the University of Rome “La Sapienza”E. Clinical and Research ActivityClinical and research activity:Both surgical and research fields of interest are mainly neurooncology (primary and metastatic spine and brain tumours), cerebrovascular surgery, degenerative disease of the spine, and in general the use of new technologies (Navigation, Laser, Neurphysiological monitoring) and minimally invasive techniquesin Neurosurgery. He has operated more 1000 cases as consultant neurosurgeon (first surgeon). He has got research grant as principal investigator in both clinical and basic research trial from the Italian National Institute of Teaching and Research for about 1000000 Euro .National Funded Grants AS Principal Investigator•2011 Research Grant from University of Rome “Sapienza”. "Role of Endothelial Rage in Vascular induced Alzheimer". Anno: 2011 - prot. C26A1128E. GRANT 15.000 euro. •2010 Research Grant from University of Rome “Sapienza” Principal Investigator: Experimental techniques of induced vasospasm in cavies. Anno: 2010 - prot. C26A104WBA. GRANT 10.000 euro. •2011: Research Grant from the Ministry of University and Research for the purchase of a Navigation system. Principal Investigator: "Surgery of glioma with the aid of Neuronavigation and advanced techniques of neuroimaging". Anno: 2011 - prot. C26G11R7F5 GRANT 200.000 EURO •2010: Research Grant from University of Rome “Sapienza” 201: President of the Medical Conference “CNS Tumours: Sapienza meets Harvard” - prot. C26C10STXC. GRANT 18.000 euro. •2009: Research Grant from Lazio Region -Ministry of Health. CRUL Project : Principal Investigator "Minimally invasive circumferential approach to the spine in both traumatic and degenerative pathology of the spine, with the aid of neuronavigation and abdominal and thoracic laparoscopic surgery." GRANT 437.346 EURO) •2011: RESEARCH GRANT FROM MINISTRY OF RESEARCH AND UNIVERSITY (PRIN 2010-2011). Principal Investigator PRIN 2011 Miur Prot. 2010ZESJWN_006 PROGETTO TRIENNALE 2011-2014: “Human recombinant lactoferrin inhibits the growth of human glioblastoma cells in vivo and in vitro: translational approach for a clinical trial” GRANT: 137.143 Euro. 7 NATIONAL PROJECT AS PARTECIPANTF: AWARDS •2003 Guidetti Prize for best Italian paper on 2003. •2004: Italian National Congress Milano SINCh 2004 Best Poster. (Surgery of Brain Tumours with the aid of Neuronavigation and advanced techniques of neuroimaging)•2005. Dr Martuza reference letter for the internship at MGH, Boston during residencyG: TEACHING at HANDS on SURGERY Courses•11-14 Agosto 2003. Miami Miller School of Medicine. Lab faculty at the "Microvascular sutures on cavies" course with prof. E.Siqueira • 2003-2008 Co-Responsible with prof. Delfini for the microsurgical training of residents at the Lab of Microsurgery at the Department of Neurosurgery of the University of Rome “Sapienza”. •2007-2014: IRCCS NEUROMED : Responsible for the monthly microsurgical training courses at IRCCS Neuromed Pozzilli (Is), University of Rome “Sapienza”. •23-07-2007 Italian National Congress (56° Congresso Nazionale SINch Società Italiana di Neurochirurgia Roma 23-26 Giugno 2007): Pre congressual Course. Director Course of Microsurgery. •17-18.7. 2008. University of Rome “Sapienza” : ADVANCED SKULL BASE COURSE: HANDS ON COURSE ON CADAVERS, LAB FACULTY •19-20 2008 Director of the Microsurgical course at the Microsurgical Lab IRCCS Neuromed Pozzilli (Is), University of Rome “Sapienza”. •13-12-2008 Director of the Microsurgical course at the Microsurgical Lab IRCCS Neuromed Pozzilli (Is), University of Rome “Sapienza”. •26-27/10- 2010 ITALIAN NEUROSURGICAL NATIONAL CONGRESS: Lab Faculty at the Pre-congressual Microsurgical Hands on Course. Milan. •2012- Bilbao 17-18 Settembre: Surgical Technology Symposium. Lecturer and invited speaker: "Frameless Stereotactic biopsy with the Navigus System" •2012- Chengdu, 27-29/9/2012 Invited speaker at the Chinese Spine National Conference on "Minimally-invasive treatment of thoracolumbar fractures" •27/05/2013: Napoli: Co-Responsible with Prof. G. Cantore of Hands on Course Microsurgery of spinal Cord on swine model at “ Centro di Biotecnologie dell’Ospedale Cardarelli di Napoli (prof. S. Cozzolino)”. •13/05/2014: Napoli: Co-Responsible with Prof. G. Cantore of the Hands on Course Microsurgery of spinal Cord on swine model at “ Centro di Biotecnologie dell’Ospedale Cardarelli di Napoli (prof. S. Cozzolino)”. •16/06/2014 e 28/7/2014: Napoli: Co-Responsible with Prof. G. Cantore of the Hands on Course Microsurgery of spinal Cord on swine model at “ Centro di Biotecnologie dell’Ospedale Cardarelli di Napoli (prof. S. Cozzolino)”. •13-14, FEBBRAIO 2015 MESSINA: MINIMALLY INVASIVE NEUROSURGICAL APPROACHES: HANDS ON COURSE AND LIVE SURGERY, LEICTURER AND LAB FACULTY